I have written five self-published books, primarily because I know the poetry and short story collcetions are difficult to get 'published' by an unknown and I simply enjoy having them inprint for myself and friends and because the relisioug/spiritual books are too controvercial for most Christian publishers and who else is interested in publishing them. But I have a novel coming up and I want to make it available to lulu pre-publishing for those currently interested in it (and keep the rights) and also query it to publishers. Will they see my previous self-publishing and pre-publishing of this novel as a bad thing?It will depend on the editor/publisher. If the manuscript is excellent, some may be willing to overlook your self-publishing.
They will not overlook run-on sentences and typos, however.